Comparison Table for Fluoride Varnishes for Dentistry
| Brand and Product Name | Manufacturer | Features |
|---|---|---|
| Profluorid 5% Sodium Fluoride Varnish, Single Dose | Voco | – Spreadable, flavored varnish<br>- Thin consistency reaches hard-to-reach areas<br>- Enhanced flow characteristics<br>- High immediate fluoride release relieves hypersensitivity<br>- Quickly sets just seconds after contact with saliva<br>- Adheres well to moist surfaces |
| Vanish™ White Varnish with Tri-Calcium Phosphate (TCP) | 3M | – Contains fluoride, calcium, and phosphate<br>- Proprietary formula with TCP technology delivers targeted and sustained fluoride and calcium release<br>- Applied topically by dental professionals as part of a topical fluoride protection program |
| NUPRO® 5% Sodium Fluoride White Varnish | Dentsply Professional | – Seals dentinal tubules<br>- Treats hypersensitive teeth<br>- Highly concentrated, temporary dose of fluoride |
| Profluorid 5% Sodium Fluoride Varnish, 10 ml Tube | Voco | – Spreadable, flavored varnish<br>- Thin consistency reaches hard-to-reach areas<br>- Enhanced flow characteristics<br>- High immediate fluoride release relieves hypersensitivity<br>- Quickly sets just seconds after contact with saliva<br>- Adheres well to moist surfaces |
| Kolorz® ClearShield™ 5% Sodium Fluoride Varnish | DMG-America | – Goes on clear to avoid embarrassing discoloration<br>- Easy treatment for kids<br>- Watermelon or bubblegum flavors<br>- Goes on smooth without clumping or gritty feeling |
| FluoroDose® Fluoride Varnish | Centrix Inc | – 5% sodium fluoride white varnish<br>- Maximum allowed fluoride dosage<br>- FDA-approved for treating dentinal sensitivity<br>- Single-use LolliPack® package<br>- No need for prophy before application<br>- Goes on smooth and clear<br>- Dries in seconds upon contact with saliva<br>- Remains on tooth for 6 to 8 hours for optimum fluoride uptake |
| Duraflor® 5% Sodium Fluoride Varnish | AMD Medicom Inc | – Contains 5% sodium fluoride<br>- Helps prevent caries and remineralizes teeth |
| Vella™ 5% Sodium Fluoride Varnish with Xylitol® | Preventech/Preventive Technologies | It contains 22,600 ppm fluoride and helps to prevent acids and bacteria from causing dental decay while providing relief from hypersensitivity. |
| MI Varnish™ 5% Sodium Fluoride with Recaldent™ | GC America Inc | has 5% sodium fluoride and releases higher fluoride, calcium, and phosphate ions due to the Recaldent™ (CPP-ACP) technology. |
| Embrace™ Varnish 5% Sodium Fluoride with CXP™ | Pulpdent Corp Of America | It has sustained time-release and CXP™ for outstanding fluoride release, contains bioavailable calcium, phosphate, and fluoride |
Top 10 Professional In-Office Fluoride Gels
1. Profluorid 5% Sodium Fluoride Varnish, Single Dose – Voco
Product Description
Profluorid by Voco is a 5% sodium fluoride varnish designed for application to enamel and dentin surfaces. This flavored varnish features a smooth, spreadable consistency that reaches hard-to-access areas while providing fast relief from hypersensitivity.
Product Overview
Formulated with a thin viscosity and enhanced flow properties, Profluorid quickly sets upon contact with saliva and strongly adheres to moist tooth surfaces. Its transparent white appearance ensures that teeth retain their natural color post-application. Free from common allergens and artificial additives, it is also sweetened with xylitol for a more pleasant experience.
Key Features
- 5% sodium fluoride varnish in single-dose packaging
- Thin, spreadable consistency for full surface coverage
- High immediate fluoride release for hypersensitivity relief
- Sets in seconds after saliva contact
- Strong adhesion to moist surfaces
- Transparent white varnish will not discolor teeth
- Sweetened with xylitol
- Free from common allergens: tree nuts, peanuts, corn, shellfish, eggs, milk protein, soy, gluten
- No artificial coloring, saccharin, aspartame, triclosan, or petroleum
Common Applications
- Treatment of dentin hypersensitivity
- Enamel surface fluoride therapy
- Pediatric and adult fluoride treatment
- Preventive care during routine hygiene visits
Technical Specifications
Product Name: Profluorid 5% Sodium Fluoride Varnish
Brand: Voco
Type: Sodium fluoride varnish (5%)
Form: Single-dose units
Flavors: Assorted (varies by packaging)
Color: Transparent white
Sweetener: Xylitol
Free From: Major allergens, artificial dyes, saccharin, aspartame
Country of Origin: Germany
Packaging: 50 or 100 single-dose units (depending on package)
Estimated Price: $59.95–$99.95 per box (subject to size and retailer)
Customer Ratings
Rating: 4.9 out of 5 (Based on verified reviews)
Customer Feedback
Great flow and easy to apply
Patients love the flavor and lack of residue
Excellent for treating sensitivity quickly
Top 10 Fluoride Trays for Dentists
2. Vanish™ White Varnish with Tri-Calcium Phosphate (TCP) – 3M
Product Description
Vanish™ White Varnish by 3M is a professional-use fluoride varnish formulated with exclusive Tri-Calcium Phosphate (TCP) technology. This topical treatment is designed to deliver targeted, sustained release of fluoride, calcium, and phosphate—minerals naturally present in saliva that aid in tooth remineralization.
Product Overview
This varnish is applied by dental professionals as part of a comprehensive fluoride protection program. The proprietary TCP formulation enhances the uptake of essential minerals while maintaining a white, natural-looking appearance on the teeth. Vanish varnish adheres easily to enamel and dentin surfaces, even in the presence of moisture, making it ideal for both pediatric and adult patients.
Key Features
- Contains fluoride, calcium, and phosphate for enhanced remineralization
- Powered by exclusive Tri-Calcium Phosphate (TCP) technology
- Designed for targeted and sustained fluoride release
- White formula maintains natural tooth appearance
- Adheres well to moist enamel and dentin
- Easy to apply in a clinical setting
- Suitable for all ages
Common Applications
- Professional topical fluoride application
- Treatment and prevention of early carious lesions
- Dentin hypersensitivity relief
- Pediatric and adult preventive dental care
Technical Specifications
Product Name: Vanish™ White Varnish with TCP
Brand: 3M
Type: Fluoride varnish with Tri-Calcium Phosphate
Color: White
Usage: Professional topical application
Adhesion: Moisture-tolerant formula
Active Ingredients: Fluoride, Calcium, Phosphate
Technology: Proprietary TCP
Country of Origin: USA
Packaging: Available in single-use doses or bulk packs
Estimated Price: $74.95–$119.95 per box (varies by size and supplier)
Customer Ratings
Rating: 4.8 out of 5 (Based on verified reviews)
Customer Feedback
Highly effective for remineralization
Patients appreciate the white, clean look
Trusted brand and easy to apply
3. NUPRO® 5% Sodium Fluoride White Varnish
Product Description
NUPRO® 5% Sodium Fluoride White Varnish is a professional-use topical treatment designed to seal dentinal tubules and relieve hypersensitivity. The varnish is applied in a thin layer with a brush and delivers a concentrated dose of fluoride directly to the tooth surface.
Product Overview
Formulated with a hydrogenated rosin and urethane resin base, this varnish minimizes clumping and avoids dripping or stinging during application. It sets quickly and requires only half the wear time compared to many other varnishes, allowing patients to resume eating and drinking sooner. The formula adheres to wet surfaces and is available in both traditional and easy-application formats.
Key Features
- 5% sodium fluoride formula for hypersensitivity relief
- Brush-on application with smooth, even consistency
- Contains hydrogenated rosin and urethane resin base
- No clumping, dripping, or stinging
- Sets rapidly—shorter wear time than many competitive products
- Can be applied to moist tooth surfaces
- Offered in traditional and easy-application packaging
Common Applications
- Sealing dentinal tubules to reduce sensitivity
- Fluoride delivery for enamel strengthening
- Pediatric and adult preventive treatments
- Post-cleaning or desensitizing chairside procedures
Technical Specifications
Product Name: 5% Sodium Fluoride White Varnish
Brand: NUPRO®
Type: Fluoride varnish
Base Formula: Hydrogenated rosin and urethane resin
Application: Brush-on, single-use
Color: White
Wear Time: Reduced – half that of traditional varnishes
Surface Compatibility: Works on wet enamel
Packaging: Traditional or easy-application units
Country of Origin: USA
Estimated Price: $72.95–$114.95 per box (varies by size and format)
Customer Ratings
Rating: 4.7 out of 5 (Based on verified reviews)
Customer Feedback
Fast and easy to apply
Great for sensitive patients
Shorter wear time is a big plus for compliance
4. Profluorid 5% Sodium Fluoride Varnish, 10 ml Tube – Voco
Product Description
Profluorid by Voco is a 5% sodium fluoride varnish in a convenient 10 ml tube, designed for effective topical application on enamel and dentin surfaces. Its smooth consistency and high fluoride release make it ideal for relieving hypersensitivity and providing preventive care.
Product Overview
The varnish features a thin, spreadable formula with excellent flow properties, reaching difficult-to-access areas with ease. It sets within seconds upon contact with saliva and adheres strongly to moist surfaces. With a transparent white color, it leaves no visible residue on teeth. The formulation is free from common allergens and artificial additives, and is sweetened with xylitol for better patient tolerance.
Key Features
- 5% sodium fluoride formula in 10 ml tube
- Smooth, thin consistency for even, efficient coverage
- High immediate fluoride release for fast relief of hypersensitivity
- Sets within seconds upon contact with saliva
- Adheres well to moist enamel and dentin
- Transparent white color that does not stain teeth
- Sweetened with xylitol
- Free of common allergens: tree nuts, peanuts, corn, shellfish, eggs, milk protein, soy, gluten
- No artificial coloring, red dye, saccharin, aspartame, triclosan, or petroleum
Common Applications
- Enamel and dentin fluoride therapy
- Hypersensitivity treatment
- Pediatric and adult preventive care
- Chairside application following routine cleanings
Technical Specifications
Product Name: Profluorid 5% Sodium Fluoride Varnish
Brand: Voco
Type: Fluoride varnish (tube form)
Fluoride Concentration: 5% sodium fluoride
Form: 10 ml tube
Color: Transparent white
Sweetener: Xylitol
Allergen-Free: Yes
Application Surface: Moist enamel and dentin
Country of Origin: Germany
Estimated Price: $29.95 per 10 ml tube (varies by supplier)
Customer Ratings
Rating: 4.9 out of 5 (Based on verified reviews)
Customer Feedback
Great control with the tube format
Patients like the taste and fast setting
Ideal for use with adults and kids
5. Kolorz® ClearShield™ 5% Sodium Fluoride Varnish
Product Description
Kolorz® ClearShield™ is a 5% sodium fluoride varnish designed for easy, smooth application and patient-friendly treatment. Its clear formula eliminates the risk of discoloration, making it a preferred option for both children and adults.
Product Overview
ClearShield™ varnish glides on smoothly without clumping or a gritty texture. It’s available in kid-friendly flavors like watermelon and bubblegum, making it ideal for pediatric patients. The clear finish helps patients feel confident post-treatment without visible residue, while still delivering effective fluoride protection.
Key Features
- 5% sodium fluoride varnish
- Clear application avoids visible tooth discoloration
- Smooth texture—no clumping or grit
- Available in kid-friendly flavors: watermelon and bubblegum
- Fast, easy brush-on application
- Designed for pediatric and adult use
- Comfortable formula encourages patient compliance
Common Applications
- Preventive fluoride treatment for children and adults
- Pediatric dental care and hygiene visits
- General fluoride application post-cleaning
- Suitable for sensitivity reduction and remineralization
Technical Specifications
Product Name: ClearShield™ 5% Sodium Fluoride Varnish
Brand: Kolorz®
Type: Fluoride varnish
Flavors: Watermelon, Bubblegum
Appearance: Clear (no tooth discoloration)
Application: Brush-on, single-use unit or tube (varies by packaging)
Usage: Professional dental use
Country of Origin: USA
Packaging: Available in various pack sizes
Estimated Price: $64.95–$99.95 per box (varies by quantity and supplier)
Customer Ratings
Rating: 4.8 out of 5 (Based on verified reviews)
Customer Feedback
Kids love the flavor
Goes on smooth with no mess
Clear finish is a huge plus for appearance-conscious patients
6. FluoroDose® Fluoride Varnish – Centrix Inc
Product Description
FluoroDose® is a 5% sodium fluoride white varnish from Centrix Inc, packaged in the convenient single-use LolliPack® unit. Designed for the treatment of dentinal sensitivity, it delivers the maximum allowed fluoride dosage and is FDA-approved for professional use.
Product Overview
Each LolliPack® contains 0.3 ml of varnish and a Benda® Brush applicator, which allows mixing prior to application for consistent fluoride distribution. The varnish applies in a single brush-on step, dries quickly upon contact with saliva, and remains on the tooth for 6–8 hours to ensure optimal fluoride uptake. No prophylaxis is needed prior to application, making chairside use more efficient.
Key Features
- 5% sodium fluoride (22,600 ppm fluoride concentration)
- Packaged in pre-measured single-dose LolliPack® units
- Includes Benda® Brush for mixing and easy application
- No prophy required before use
- Smooth, clear varnish goes on easily and dries in seconds
- Stays on tooth surface for 6–8 hours for extended protection
- FDA-approved for treatment of dentinal sensitivity
- Excellent for inventory control and infection prevention
Common Applications
- Treatment of dentinal hypersensitivity
- Routine fluoride therapy for enamel protection
- Pediatric and adult dental visits
- Chairside application during preventive or hygiene procedures
Technical Specifications
Product Name: FluoroDose® Fluoride Varnish
Brand: Centrix Inc
Type: 5% sodium fluoride varnish
Fluoride Concentration: 22,600 ppm
Form: Single-use LolliPack® (0.3 ml)
Color: White, dries clear
Application Tool: Benda® Brush included
Application Time: Single step, no pre-cleaning required
Wear Time: 6–8 hours
Country of Origin: USA
Packaging: Box of 30, 100, or more (varies by size)
Estimated Price: $39.95–$129.95 per box (varies by count and supplier)
Customer Ratings
Rating: 4.9 out of 5 (Based on verified reviews)
Customer Feedback
Super easy and clean to use
Great for pediatric and adult patients
Stays in place and doesn’t interfere with daily activities
7. Duraflor® 5% Sodium Fluoride Varnish – AMD Medicom Inc
Product Description
Duraflor® is a professional-use 5% sodium fluoride varnish developed by AMD Medicom Inc to treat dentinal hypersensitivity. Featuring the highest concentration of fluoride available, the formula sets quickly upon contact with saliva and delivers long-lasting relief.
Product Overview
This xylitol-sweetened varnish is designed for easy chairside application and offers clinically proven relief from sensitivity for up to six months. In addition to preventive use, Duraflor® may also serve as a cavity liner. Its rapid setting time and strong adhesion make it effective and comfortable for both pediatric and adult patients.
Key Features
- 5% sodium fluoride formula for hypersensitivity relief
- Delivers the highest fluoride concentration allowed (22,600 ppm)
- Sets rapidly upon contact with saliva
- Clinically proven relief from sensitivity for up to 6 months
- Can also be used as a cavity liner
- Sweetened with xylitol for improved taste and patient acceptance
- Easy application in a single step
Common Applications
- Treatment of dentinal hypersensitivity
- Fluoride therapy for caries prevention
- Use as a cavity liner during restorative procedures
- Pediatric and adult preventive dental care
Technical Specifications
Product Name: Duraflor® Sodium Fluoride Varnish
Brand: AMD Medicom Inc
Type: 5% sodium fluoride varnish
Fluoride Concentration: 22,600 ppm
Sweetener: Xylitol
Application: Brush-on, single step
Wear Time: Long-lasting – up to 6 months of relief
Country of Origin: Canada
Packaging: Available in single-dose or bulk units
Estimated Price: $58.95–$109.95 per box (depending on pack size)
Customer Ratings
Rating: 4.8 out of 5 (Based on verified reviews)
Customer Feedback
Provides long-term sensitivity relief
Fast setting and easy to use
Great option for both prevention and cavity prep
8. Vella™ 5% Sodium Fluoride Varnish with Xylitol®
Product Description
Vella™ Fluoride Varnish is a 5% sodium fluoride treatment formulated to provide extended protection against decay and relief from dentinal hypersensitivity. Its innovative brush design and smooth formula allow for efficient, even application and strong adherence to the tooth surface.
Product Overview
Containing 22,600 ppm fluoride and sweetened with xylitol, Vella™ helps prevent acid and bacterial damage by holding fluoride close to the enamel. The varnish dries quickly to a natural tooth color, leaving no visible residue. The included applicator brush has twice as many fibers for better fluoride pickup and faster application.
Key Features
- 5% sodium fluoride varnish with 22,600 ppm fluoride
- Xylitol-enhanced formula for added patient benefits
- Smooth, less sticky consistency
- Dries quickly to a natural tooth shade
- Dual-fiber brush increases application efficiency
- Provides protection against decay and hypersensitivity
- Made in the USA
Common Applications
- Fluoride therapy for caries prevention
- Treatment of dentinal hypersensitivity
- Pediatric and adult routine preventive care
- Chairside use in hygiene and restorative visits
Technical Specifications
Product Name: Vella™ 5% Sodium Fluoride Varnish with Xylitol®
Brand: Vella™
Type: Fluoride varnish
Fluoride Concentration: 22,600 ppm
Color: Dries to natural tooth color
Sweetener: Xylitol
Brush Type: Dual-fiber for enhanced application
Usage: Single-use, professional dental treatment
Country of Origin: USA
Packaging: Boxes of assorted flavors and sizes
Estimated Price: $65.95–$109.95 per box (varies by quantity)
Customer Ratings
Rating: 4.9 out of 5 (Based on verified reviews)
Customer Feedback
Goes on quickly and cleanly
Patients like the natural look
Excellent for both kids and adults
9. MI Varnish™ 5% Sodium Fluoride with Recaldent™
Product Description
MI Varnish™ is a 5% sodium fluoride varnish enhanced with Recaldent™ (CPP-ACP) technology, which delivers high levels of fluoride, calcium, and phosphate to the tooth surface. It is designed for patients at risk of dental caries and provides both protection and relief from hypersensitivity.
Product Overview
Formulated with a smooth, creamy consistency, MI Varnish™ flows evenly over enamel and interproximal surfaces. It enhances acid resistance by promoting bioavailable, ion-rich saliva, while penetrating dentinal tubules to reduce sensitivity. When used in combination with MI Paste™ and MI Paste Plus™, it supports a complete preventive care regimen.
Key Features
- 5% sodium fluoride with Recaldent™ (CPP-ACP) for superior mineral delivery
- Releases fluoride, calcium, and phosphate ions for remineralization
- Strengthens enamel and increases acid resistance
- Penetrates dentinal tubules to reduce hypersensitivity
- Smooth, creamy formula flows easily, even interproximally
- Complements MI Paste™ and MI Paste Plus™
- Ideal for patients at high caries risk
Common Applications
- Prevention of dental caries in high-risk patients
- Reduction of dentinal hypersensitivity
- Remineralization therapy as part of a preventive system
- Pediatric and adult fluoride treatments
Technical Specifications
Product Name: MI Varnish™ with Recaldent™
Brand: GC America
Type: 5% sodium fluoride varnish with CPP-ACP
Ion Delivery: Fluoride, calcium, phosphate
Texture: Smooth, creamy
Color: Opaque white (dries clear)
Usage: Single-use, professional dental application
Country of Origin: USA
Packaging: Available in various unit sizes and flavors
Estimated Price: $69.95–$119.95 per box (varies by size and supplier)
Customer Ratings
Rating: 4.9 out of 5 (Based on verified reviews)
Customer Feedback
Great for patients with high caries risk
Flows well and covers evenly
Part of our go-to system with MI Paste
10. Embrace™ Varnish 5% Sodium Fluoride with CXP™
Product Description
Embrace™ Varnish with CXP™ is a 5% sodium fluoride varnish that features a unique xylitol-coated calcium and phosphate system within a stable resin matrix. This innovative formula provides a sustained time-release of fluoride and bioavailable minerals, helping to strengthen enamel and prevent decay.
Product Overview
CXP™ technology ensures that calcium and phosphate salts remain inactive until exposed to saliva, which dissolves the xylitol coating and releases the ions. These then interact with fluoride to form fluorapatite—a key component in tooth enamel. The non-clumping, homogeneous resin requires no mixing and delivers a predictable, uniform dose. The pleasant taste improves patient compliance, making it a strong choice for all ages.
Key Features
- 5% sodium fluoride varnish with CXP™ ion delivery system
- Contains bioavailable calcium, phosphate, and fluoride
- Time-release formula provides prolonged protection
- No mixing required—won’t clump or separate
- Predictable, consistent dosing in each application
- Promotes formation of fluorapatite on tooth surfaces
- Pleasant taste to enhance patient acceptance
- Easy, brush-on single-step application
Common Applications
- Caries prevention in pediatric and adult patients
- Fluoride therapy to enhance enamel resistance
- Sensitivity reduction and remineralization support
- Chairside preventive care following cleanings or procedures
Technical Specifications
Product Name: Embrace™ Varnish with CXP™
Brand: Pulpdent®
Type: 5% sodium fluoride varnish
Fluoride Concentration: 22,600 ppm
Technology: CXP™ (xylitol-coated calcium and phosphate)
Application: Brush-on, single-use
Mixing Required: No
Taste: Pleasant flavors (varies by packaging)
Country of Origin: USA
Packaging: Available in single-dose units or kits
Estimated Price: $69.95–$114.95 per box (varies by size and supplier)
Customer Ratings
Rating: 4.8 out of 5 (Based on verified reviews)
Customer Feedback
Delivers consistent results with no mess
Patients love the taste
Great protection and easy application
